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| Cat.No | ACP10148 | Target Name | BAG5 |
|---|---|---|---|
| Target Synonyms | BAG family molecular chaperone regulator 5; BAG-5; BAG5; BAG5_HUMAN; Bcl 2 associated athanogene 5; Bcl-2-associated athanogene 5; BCL2 associated athanogene 5; KIAA0873 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-447 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UL15 |
|---|
Uniprot Id
Q9UL15
Target Species
Human
Target Name
BAG5
Target Full Name
BAG family molecular chaperone regulator 5
Target Function
Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
Target Research Area
Cancer
Target Synonyms
BAG family molecular chaperone regulator 5; BAG-5; BAG5; BAG5_HUMAN; Bcl 2 associated athanogene 5; Bcl-2-associated athanogene 5; BCL2 associated athanogene 5; KIAA0873
Target Background
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.
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