Recombinant Human BAI1-associated protein 3 (BAIAP3), Truncated

Uniprot Id

O94812

Target Species

Human

Target Name

BAIAP3

Target Full Name

BAI1-associated protein 3

Target Function

Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin. Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission.

Target Subcellular Location

Cytoplasm, cytosol. Recycling endosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein.

Target Protein Families

Unc-13 family

Target Tissue Specificity

Predominantly expressed in brain. Also expressed in nonneural tissues such as breast and testes epithelium.

Target Synonyms

BAI1 associated protein 3; BAI1-associated protein 3; Baiap3; BAIP3_HUMAN; BAP2; BAP3