Recombinant Human Bcl-2-related protein A1 (BCL2A1)

Cat.No	ACP01354	Target Name	BCL2A1
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-175aa	Mol Weight	51.6 kDa
Protein Length	Full length	Purity	Greater than 85% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP01354

Target Name

BCL2A1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-175aa

Mol Weight

51.6 kDa

Protein Length

Full length

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q16548

Background Information

Uniprot Id

Q16548
Target Species

Human
Target Name

BCL2A1
Target Full Name

Bcl-2-related protein A1
Target Function

Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11.
Target Subcellular Location

Cytoplasm.
Target Protein Families

Bcl-2 family
Target Tissue Specificity

Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and h
Target Research Area

Cell Biology
Target Synonyms

ACC 1; ACC 2 ; B2LA1_HUMAN; Bcl 2 related protein A1; Bcl-2-like protein 5; Bcl-2-related protein A1; BCL2 related protein A1; Bcl2-L-5; BCL2A1; BCL2L5 ; BFL1 ; GRS ; HBPA1 ; Hematopoietic BCL2 related protein A1 ; Hemopoietic specific early response protein; Hemopoietic-specific early response protein; Protein BFL 1; Protein BFL-1; Protein GRS
Target Background

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Bcl-2-related protein A1 (BCL2A1)

Specifications

Immunogen Information

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