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| Cat.No | ACP03849 | Target Name | BEND3 |
|---|---|---|---|
| Target Synonyms | BEN domain containing 3; BEN domain-containing protein 3; Bend3; BEND3_HUMAN; KIAA1553; RP11-59I9.2 | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 328-461aa |
| Mol Weight | 17.5kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5T5X7 |
|---|
Uniprot Id
Q5T5X7
Target Species
Human
Target Name
BEND3
Target Full Name
BEN domain-containing protein 3
Target Function
Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination. Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. Stimulates the ERCC6L translocase and ATPase activities.
Target Subcellular Location
Nucleus. Nucleus, nucleolus.
Target Tissue Specificity
Expressed at least in heart, kidney, liver, ovary and spleen, with highest levels in spleen and lowest in heart. Expressed on the surface of T-cells.
Target Research Area
Cardiovascular
Target Synonyms
BEN domain containing 3; BEN domain-containing protein 3; Bend3; BEND3_HUMAN; KIAA1553; RP11-59I9.2
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