Recombinant Human Beta-1 adrenergic receptor (ADRB1)

Uniprot Id

P08588

Target Species

Human

Target Name

ADRB1

Target Full Name

Beta-1 adrenergic receptor

Target Function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Early endosome.

Target Protein Families

G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB1 sub-subfamily

Target Research Area

Cardiovascular

Target Synonyms

ADRB1; ADRB1R; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor

Target Background

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Beta-1 adrenoceptors are predominately located in the heart. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.