Recombinant Human Beta-secretase 2 (BACE2), Truncated

Cat.No	ACP09673	Target Name	BACE2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP09673

Target Name

BACE2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9Y5Z0

Background Information

Uniprot Id

Q9Y5Z0
Target Species

Human
Target Name

BACE2
Target Full Name

Beta-secretase 2
Target Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome.
Target Protein Families

Peptidase A1 family
Target Tissue Specificity

Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed
Target Synonyms

ALP 56; ALP56; Asp 1; ASP1; ASP21; Aspartic Like Protease 56kDa; Aspartic-like protease 56 kDa; Aspartyl protease 1; BACE 2; Bace2; BACE2_HUMAN; Beta Secretase 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta-secretase 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin 1; Memapsin-1; Membrane associated aspartic protease 1; Membrane-associated aspartic protease 1; Theta-secretase
Target Background

This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.

Recombinant Human Beta-secretase 2 (BACE2), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Beta-secretase 2 (BACE2), Truncated Now

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