Recombinant Human Bifunctional 3′-phosphoadenosine 5′-phosphosulfate synthase 2 (PAPSS2)

Uniprot Id

O95340

Target Species

Human

Target Name

PAPSS2

Target Full Name

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

Target Function

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases. In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway. Plays indirectly an important role in skeletogenesis during postnatal growth.

Target Involvement

Brachyolmia type 4 with mild epiphyseal and metaphyseal changes (BCYM4)

Target Protein Families

APS kinase family; Sulfate adenylyltransferase family

Target Tissue Specificity

Expressed in cartilage and adrenal gland.

Target Synonyms

PAPSS2; ATPSK2Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2; PAPS synthase 2; PAPSS 2; Sulfurylase kinase 2; SK 2; SK2) [Includes: Sulfate adenylyltransferase; EC 2.7.7.4; ATP-sulfurylase; Sulfate adenylate transferase; SAT); Adenylyl-sulfate kinase; EC 2.7.1.25; 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase)]