Recombinant Human Blood group Rh (D) polypeptide (RHD), Truncated

Uniprot Id

Q02161

Target Species

Human

Target Name

RHD

Target Full Name

Blood group Rh(D) polypeptide

Target Function

May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Ammonium transporter (TC 2.A.49) family, Rh subfamily

Target Tissue Specificity

Restricted to tissues or cell lines expressing erythroid characters.

Target Research Area

Cardiovascular

Target Synonyms

RHD; Blood group Rh(D polypeptide; RHXIII; Rh polypeptide 2; RhPII; Rhesus D antigen; CD antigen CD240D

Target Background

The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene.