Recombinant Human BMP and activin membrane-bound inhibitor homolog (BAMBI), Truncated

Uniprot Id

Q13145

Target Species

Human

Target Name

BAMBI

Target Full Name

BMP and activin membrane-bound inhibitor homolog

Target Function

Negatively regulates TGF-beta signaling.

Target Subcellular Location

Membrane; Single-pass type I membrane protein.

Target Protein Families

BAMBI family

Target Tissue Specificity

High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.

Target Synonyms

BAMBI; BAMBI_HUMAN; BMP and activin membrane bound inhibitor homolog; BMP and activin membrane-bound inhibitor homolog; NMA; Non metastatic gene A protein; Non-metastatic gene A protein; Putative transmembrane protein NMA

Target Background

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.