Recombinant Human Bone morphogenetic protein 1 (BMP1)

Cat.No	ACP04884	Target Name	BMP1
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	121-986aa	Mol Weight	102.0kDa
Protein Length	Full Length of Mature Protein	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04884

Target Name

BMP1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

121-986aa

Mol Weight

102.0kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P13497

Background Information

Uniprot Id

P13497
Target Species

Human
Target Name

BMP1
Target Full Name

Bone morphogenetic protein 1
Target Function

Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation.; Plays an important role in bone repair by acting as a coactivator of BMP7.
Target Involvement

Osteogenesis imperfecta 13 (OI13)
Target Subcellular Location

Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Secreted.; [Isoform BMP1-3]: Secreted.
Target Protein Families

Peptidase M12A family
Target Tissue Specificity

Ubiquitous.
Target Research Area

Developmental Biology
Target Synonyms

BMP 1; BMP-1; BMP1; BMP1_HUMAN; Bone morphogenetic protein 1; Mammalian tolloid protein; mTld; OI13; PCOLC; PCP; PCP2; Procollagen C endopeptidase; Procollagen C proteinase; Procollagen C-proteinase; TLD; Tolloid; Drosophila; homolog of
Target Background

This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region.

Recombinant Human Bone morphogenetic protein 1 (BMP1)

Specifications

Immunogen Information

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