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The recombinant Human GDF10 protein production is achieved through the manipulation of desired gene expression in e.coli cells. The sequence (369-478aa) of foreign DNA is fused to an expression vector and then transformed into e.coli cells. The positive cells are selected and cultured to induce the expression of the desired protein. A N-terminal 10xHis tag is fused to the protein. The recombinant Human GDF10 protein is subjected to affinity purification. Its purity is over 90%, as measured by SDS-PAGE.
The recombinant Human GDF10 protein production is achieved through the manipulation of desired gene expression in e.coli cells. The sequence (369-478aa) of foreign DNA is fused to an expression vector and then transformed into e.coli cells. The positive cells are selected and cultured to induce the expression of the desired protein. A N-terminal 10xHis tag is fused to the protein. The recombinant Human GDF10 protein is subjected to affinity purification. Its purity is over 90%, as measured by SDS-PAGE.
| Cat.No | ACP01217 | Target Name | GDF10 |
|---|---|---|---|
| Target Synonyms | (GDF-10)(Bone morphogenetic protein 3B)(BMP-3B)(Bone-inducing protein)(BIP) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 369-478aa |
| Mol Weight | 16.1 kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P55107 |
|---|
Uniprot Id
P55107
Target Species
Human
Target Name
GDF10
Target Full Name
Growth/differentiation factor 10
Target Function
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Target Subcellular Location
Secreted.
Target Protein Families
TGF-beta family
Target Tissue Specificity
Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
Target Research Area
Cancer
Target Synonyms
BIP; BMP 3b; BMP-3b; BMP3B; BMP3B_HUMAN; Bone inducing protein; Bone morphogenetic protein 3b [Precursor]; Bone morphogenetic protein 3b; Bone-inducing protein; GDF 10; GDF-10; Gdf10; growth differentiation factor 10; Growth/differentiation factor 10
Target Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer.
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