Recombinant Human Bone morphogenetic protein 3B (GDF10)

Uniprot Id

P55107

Target Species

Human

Target Name

GDF10

Target Full Name

Growth/differentiation factor 10

Target Function

Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.

Target Subcellular Location

Secreted.

Target Protein Families

TGF-beta family

Target Tissue Specificity

Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.

Target Research Area

Cancer

Target Synonyms

BIP; BMP 3b; BMP-3b; BMP3B; BMP3B_HUMAN; Bone inducing protein; Bone morphogenetic protein 3b [Precursor]; Bone morphogenetic protein 3b; Bone-inducing protein; GDF 10; GDF-10; Gdf10; growth differentiation factor 10; Growth/differentiation factor 10

Target Background

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This promotes neural repair after stroke. Additionally, this protein may act as a tumor suppressor and reduced expression of this gene is associated with oral cancer.