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Discover the potential of Brain-derived neurotrophic factor (BDNF) in your neuroscience research with our superior Recombinant Human BDNF protein. BDNF, also known as Abrineurin, is a neurotrophin that plays a crucial role in the survival, growth, and differentiation of neurons in the central and peripheral nervous systems. It is involved in synaptic plasticity, learning, memory, and neuronal regeneration, making it a vital protein for researchers in neurodegenerative diseases, neuropsychiatric disorders, and neural injury studies. Our Recombinant Human BDNF protein is expressed in E. coli, ensuring a consistent and reliable product for your research needs. The partial protein length, covering the expression region from 137-237aa, retains the essential functional domains of BDNF. An N-terminal GST tag has been added to our recombinant BDNF protein to facilitate easy protein purification and detection. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human BDNF protein is supplied as a lyophilized powder, providing you with a dependable and effective tool for your neuroscience research projects.
Discover the potential of Brain-derived neurotrophic factor (BDNF) in your neuroscience research with our superior Recombinant Human BDNF protein. BDNF, also known as Abrineurin, is a neurotrophin that plays a crucial role in the survival, growth, and differentiation of neurons in the central and peripheral nervous systems. It is involved in synaptic plasticity, learning, memory, and neuronal regeneration, making it a vital protein for researchers in neurodegenerative diseases, neuropsychiatric disorders, and neural injury studies.
Our Recombinant Human BDNF protein is expressed in E. coli, ensuring a consistent and reliable product for your research needs. The partial protein length, covering the expression region from 137-237aa, retains the essential functional domains of BDNF. An N-terminal GST tag has been added to our recombinant BDNF protein to facilitate easy protein purification and detection. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human BDNF protein is supplied as a lyophilized powder, providing you with a dependable and effective tool for your neuroscience research projects.
| Cat.No | ACP02944 | Target Name | BDNF |
|---|---|---|---|
| Target Synonyms | Abrineurin; ANON2; BDNF; BDNF_HUMAN; Brain Derived Neurotrophic Factor; Brain-derived neurotrophic factor; BULN2; MGC34632; Neurotrophin | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 137-237aa |
| Mol Weight | 38.5kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P23560 |
|---|
Uniprot Id
P23560
Target Species
Human
Target Name
BDNF
Target Full Name
Neurotrophic factor BDNF precursor form
Target Function
Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.; Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse.
Target Involvement
Bulimia nervosa 2 (BULN2); Congenital central hypoventilation syndrome (CCHS)
Target Subcellular Location
Secreted.; [BDNF precursor form]: Secreted.
Target Protein Families
NGF-beta family
Target Tissue Specificity
Detected in blood plasma and in saliva (at protein level). Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
Target Research Area
Neuroscience
Target Synonyms
Abrineurin; ANON2; BDNF; BDNF_HUMAN; Brain Derived Neurotrophic Factor; Brain-derived neurotrophic factor; BULN2; MGC34632; Neurotrophin
Target Background
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders.
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