Recombinant Human BRCA1-A complex subunit Abraxas (FAM175A)

Uniprot Id

Q6UWZ7

Target Species

Human

Target Name

ABRAXAS1

Target Full Name

BRCA1-A complex subunit Abraxas 1

Target Function

Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

Target Involvement

Breast cancer (BC)

Target Subcellular Location

Nucleus.

Target Protein Families

FAM175 family, Abraxas subfamily

Target Synonyms

3830405G04Rik; 5630400M01Rik; ABRA1; ABRAXAS; Abraxas protein; AI506069; AL024423; AV118690; BRCA1-A complex subunit Abraxas; coiled coil domain containing 98; Coiled-coil domain-containing protein 98; F175A_HUMAN; FAM175A; Family with sequence similarity 175 member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A

Target Background

This gene encodes a protein that binds to the C-terminal repeats of breast cancer 1 (BRCA1) through a phospho-SXXF motif. The encoded protein recruits ubiquitin interaction motif containing 1 protein to BRCA1 protein and is required for DNA damage resistance, DNA repair, and cell cycle checkpoint control. Pseudogenes of this gene are found on chromosomes 3 and 8. Alternative splicing results in multiple transcript variants.