Recombinant Human BRCA1-associated protein (BRAP)

Uniprot Id

Q7Z569

Target Species

Human

Target Name

BRAP

Target Full Name

BRCA1-associated protein

Target Function

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

Target Subcellular Location

Cytoplasm.

Target Tissue Specificity

Expressed in breast epithelial cell lines.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

BRAP; RNF52BRCA1-associated protein; EC 2.3.2.27; BRAP2; Impedes mitogenic signal propagation; IMP; RING finger protein 52; RING-type E3 ubiquitin transferase BRAP2; Renal carcinoma antigen NY-REN-63

Target Background

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm.