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| Cat.No | ACP19100 | Target Name | BIN2 |
|---|---|---|---|
| Target Synonyms | BIN2; BRAP1Bridging integrator 2; Breast cancer-associated protein 1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-565 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UBW5 |
|---|
Uniprot Id
Q9UBW5
Target Species
Human
Target Name
BIN2
Target Full Name
Bridging integrator 2
Target Function
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
Target Subcellular Location
Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cell projection, phagocytic cup.
Target Tissue Specificity
Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.
Target Synonyms
BIN2; BRAP1Bridging integrator 2; Breast cancer-associated protein 1
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