Recombinant Human BRISC complex subunit Abro1 (FAM175B)

Uniprot Id

Q15018

Target Species

Human

Target Name

ABRAXAS2

Target Full Name

BRISC complex subunit Abraxas 2

Target Function

Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm. Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. Required for normal induction of p53/TP53 in response to DNA damage. Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage

Target Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton.

Target Protein Families

FAM175 family, Abro1 subfamily

Target Tissue Specificity

Detected in heart muscle (at protein level). Detected in heart and muscle, and at much lower levels in brain.

Target Research Area

Cell Biology

Target Synonyms

ABRAXAS2; ABRO1; FAM175B; KIAA0157BRISC complex subunit Abraxas 2; Abraxas brother protein 1; Protein FAM175B