Recombinant Human Bromodomain adjacent to zinc finger domain protein 2B (BAZ2B), Truncated

Uniprot Id

Q9UIF8

Target Species

Human

Target Name

BAZ2B

Target Full Name

Bromodomain adjacent to zinc finger domain protein 2B

Target Function

Regulatory subunit of the ATP-dependent BRF-1 and BRF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The BRF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the BRF-5 ISWI chromatin remodeling complex. Chromatin reader protein, which may play a role in transcriptional regulation via interaction with ISWI. Involved in positively modulating the rate of age-related behavioral deterioration. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with histone methyltransferase EHMT1.

Target Subcellular Location

Nucleus.

Target Protein Families

WAL family

Target Tissue Specificity

Expressed at varying levels in several tissues, whereas a smaller transcript was expressed specifically in testis.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

BAZ2B; BAZ2B_HUMAN; Bromodomain adjacent to zinc finger domain 2B; Bromodomain adjacent to zinc finger domain protein 2B; DKFZp434H071; DKFZp762I0516; FLJ45644; hWALp4; OTTHUMP00000162897; OTTHUMP00000162898; WALp4