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| Cat.No | ACP13107 | Target Name | KCTD17 |
|---|---|---|---|
| Target Synonyms | BTB; BTB/POZ domain-containing protein KCTD17; FLJ12242; FLJ98761; KCD17_HUMAN; KCTD17; Potassium channel tetramerisation domain containing 17; POZ domain-containing protein KCTD17; RP5-1170K4.4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-321 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N5Z5 |
|---|
Uniprot Id
Q8N5Z5
Target Species
Human
Target Name
KCTD17
Target Full Name
BTB/POZ domain-containing protein KCTD17
Target Function
Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation. May be involved in endoplasmic reticulum calcium ion homeostasis.
Target Involvement
Dystonia 26, myoclonic (DYT26)
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Highly expressed in brain. Highest expression is observed in the putamen and the thalamus.
Target Synonyms
BTB; BTB/POZ domain-containing protein KCTD17; FLJ12242; FLJ98761; KCD17_HUMAN; KCTD17; Potassium channel tetramerisation domain containing 17; POZ domain-containing protein KCTD17; RP5-1170K4.4
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