Home Products Recombinant Human BTB/POZ domain-containing protein KCTD6 (KCTD6)

Recombinant Human BTB/POZ domain-containing protein KCTD6 (KCTD6)

ACP14561

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Specifications

Cat.No	ACP14561	Target Name	KCTD6
Target Synonyms	BTB/POZ domain-containing protein KCTD6; KCASH3; kctd6; KCTD6_HUMAN; MGC27385; potassium channel tetramerization domain containing 6	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-237
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8NC69

Background Information

Uniprot Id

Q8NC69
Target Species

Human
Target Name

KCTD6
Target Full Name

BTB/POZ domain-containing protein KCTD6
Target Function

Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation.
Target Subcellular Location

Cytoplasm, myofibril, sarcomere, M line.
Target Tissue Specificity

Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma.
Target Synonyms

BTB/POZ domain-containing protein KCTD6; KCASH3; kctd6; KCTD6_HUMAN; MGC27385; potassium channel tetramerization domain containing 6

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Recombinant Human BTB/POZ domain-containing protein KCTD6 (KCTD6)

Specifications

Immunogen Information

Inquire Recombinant Human BTB/POZ domain-containing protein KCTD6 (KCTD6) Now

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