Recombinant Human C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9), Truncated

Uniprot Id

O60271

Target Species

Human

Target Name

SPAG9

Target Full Name

C-Jun-amino-terminal kinase-interacting protein 4

Target Function

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking.

Target Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Lysosome membrane.; [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome.

Target Protein Families

JIP scaffold family

Target Tissue Specificity

Expressed only in testis on the round spermatids of stage I, II and II. Absent in spermatogonia and spermatocyte.; [Isoform 4]: Expressed in testis and in acute myeloid leukemia (AML) patients.; [Isoform 3]: Expressed in testis.

Target Research Area

Developmental Biology

Target Synonyms

SPAG9; HSS; KIAA0516; MAPK8IP4; SYD1; HLC6C-Jun-amino-terminal kinase-interacting protein 4; JIP-4; JNK-interacting protein 4; Cancer/testis antigen 89; CT89; Human lung cancer oncogene 6 protein; HLC-6; JNK-associated leucine-zipper protein; JLP; Mitogen-activated protein kinase 8-interacting protein 4; Proliferation-inducing protein 6; Protein highly expressed in testis; PHET; Sperm surface protein; Sperm-associated antigen 9; Sperm-specific protein; Sunday driver 1