Recombinant Human C-type lectin domain family 12 member A (CLEC12A), Truncated

Uniprot Id

Q5QGZ9

Target Species

Human

Target Name

CLEC12A

Target Full Name

C-type lectin domain family 12 member A

Target Function

Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization.

Target Tissue Specificity

Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leuko

Target Synonyms

C-type lectin domain family 12 member A; C-type lectin-like molecule 1; CL12A_HUMAN; CLEC12A; CLL-1; DCAL-2; Dendritic cell-associated lectin 2; MICL; Myeloid inhibitory C-type lectin-like receptor

Target Background

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.