Recombinant Human C-type lectin domain family 2 member D (CLEC2D), Truncated

Uniprot Id

Q9UHP7

Target Species

Human

Target Name

CLEC2D

Target Full Name

C-type lectin domain family 2 member D

Target Function

Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon-gamma. Binds high molecular weight sulfated glycosaminoglycans.

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Endoplasmic reticulum.; [Isoform 4]: Endoplasmic reticulum.

Target Tissue Specificity

Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyt

Target Synonyms

C type lectin related f; C type lectin superfamily 2; member D; C-type lectin domain family 2 member D; CLAX; CLC2D_HUMAN; CLEC2D; CLEC2D protein; Clec2d5 ; L LT1; Lectin like NK cell receptor ; Lectin like transcript 1; Lectin-like NK cell receptor; Lectin-like transcript 1; LLT-1; LLT1; OCIL; Osteoclast inhibitory lectin

Target Background

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.