Recombinant Human C-type lectin domain family 4 member C (CLEC4C), Truncated

Cat.No	ACP02597	Target Name	CLEC4C
Form	Liquid or Lyophilized powder	Expression System	Mammalian cell
Expression Range	45-213aa	Mol Weight	24.0kDa
Protein Length	Extracellular Domain	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02597

Target Name

CLEC4C

Form

Liquid or Lyophilized powder

Expression System

Mammalian cell

Expression Range

45-213aa

Mol Weight

24.0kDa

Protein Length

Extracellular Domain

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8WTT0

Background Information

Uniprot Id

Q8WTT0
Target Species

Human
Target Name

CLEC4C
Target Full Name

C-type lectin domain family 4 member C
Target Function

Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.
Target Tissue Specificity

Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
Target Research Area

Immunology
Target Synonyms

CLEC4C; BDCA2; CLECSF11; CLECSF7; DLEC; HECL; UNQ9361/PRO34150C-type lectin domain family 4 member C; Blood dendritic cell antigen 2; BDCA-2; C-type lectin superfamily member 7; Dendritic lectin; CD antigen CD303
Target Background

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene.

Recombinant Human C-type lectin domain family 4 member C (CLEC4C), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human C-type lectin domain family 4 member C (CLEC4C), Truncated Now

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