Recombinant Human C-type lectin domain family 4 member G (CLEC4G), Truncated

Cat.No	ACP16440	Target Name	CLEC4G
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP16440

Target Name

CLEC4G

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q6UXB4

Background Information

Uniprot Id

Q6UXB4
Target Species

Human
Target Name

CLEC4G
Target Full Name

C-type lectin domain family 4 member G
Target Function

Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro.; (Microbial infection) Acts as a receptor for Japanese encephalitis virus.; (Microbial infection) Acts as a receptor for Ebolavirus.; (Microbial infection) Acts as a receptor for SARS-CoV.; (Microbial infection) Acts as a receptor for Lassa virus and Lymphocytic choriomeningitis virus glycoprotein.
Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.
Target Tissue Specificity

Expressed exclusively in fetal and adult liver and in lymph nodes. Specifically expressed by endothelial cells lining lymph node and liver sinuses (at protein level).
Target Synonyms

C type lectin domain family 4; member G; C type lectin superfamily 4; member G; C-type lectin domain family 4 member G; CLC4G_HUMAN; Clec4g; DTTR431; Liver and lymph node sinusoidal endothelial cell C type lectin; LP2698; LSECtin; UNQ431
Target Background

This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene's protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene.

Recombinant Human C-type lectin domain family 4 member G (CLEC4G), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human C-type lectin domain family 4 member G (CLEC4G), Truncated Now

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