Recombinant Human C-type lectin domain family 6 member A (CLEC6A), Truncated

Cat.No	ACP16594	Target Name	CLEC6A
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP16594

Target Name

CLEC6A

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q6EIG7

Background Information

Uniprot Id

Q6EIG7
Target Species

Human
Target Name

CLEC6A
Target Full Name

C-type lectin domain family 6 member A
Target Function

Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.
Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.
Target Tissue Specificity

Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.
Target Synonyms

C type lectin domain family 6 member A; C type lectin superfamily member 10; C-type (calcium dependent; carbohydrate-recognition domain) lectin; superfamily member 10; C-type lectin domain family 6 member A; C-type lectin superfamily member 10; CLC6A_HUMAN; CLEC4N; CLEC4N; mouse; homolog of; Clec6a; CLECSF10; DC associated C type lectin 2; DC-associated C-type lectin 2; Dectin-2; Dectin2; Dendritic cell associated lectin 2; Dendritic cell-associated C-type lectin 2

Recombinant Human C-type lectin domain family 6 member A (CLEC6A), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human C-type lectin domain family 6 member A (CLEC6A), Truncated Now

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