Recombinant Human CAD protein (CAD), Truncated

Uniprot Id

P27708

Target Species

Human

Target Name

CAD

Target Full Name

Multifunctional protein CAD

Target Function

This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).

Target Involvement

Epileptic encephalopathy, early infantile, 50 (EIEE50)

Target Subcellular Location

Cytoplasm. Nucleus. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.

Target Protein Families

Metallo-dependent hydrolases superfamily, DHOase family, CAD subfamily

Target Research Area

Others

Target Synonyms

CAD; CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase; EC 6.3.5.5); Aspartate carbamoyltransferase; EC 2.1.3.2); Dihydroorotase; EC 3.5.2.3)]

Target Background

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.