Recombinant Human Cadherin-10 (CDH10), Truncated

Uniprot Id

Q9Y6N8

Target Species

Human

Target Name

CDH10

Target Full Name

Cadherin-10

Target Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.

Target Synonyms

CAD10_HUMAN; Cadherin 10 (T2 cadherin); Cadherin 10 type 2 (T2 cadherin); Cadherin 10 type 2; Cadherin-10; Cadherin10; CDH10; T2 cadherin; T2-cadherin

Target Background

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients.