Recombinant Human Cadherin-3 (CDH3), Truncated

Uniprot Id

P22223

Target Species

Human

Target Name

CDH3

Target Full Name

Cadherin-3

Target Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Target Involvement

Hypotrichosis congenital with juvenile macular dystrophy (HJMD); Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Tissue Specificity

Expressed in some normal epithelial tissues and in some carcinoma cell lines.

Target Synonyms

CDH3; CDHP; Cadherin-3; Placental cadherin; P-cadherin

Target Background

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS).