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Recombinant Human Calcineurin B homologous protein 2 (CHP2)

ACP19751

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP19751 Target NameCHP2
Target SynonymsCHP2; HCA520Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520FormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Expression Range2-196
Protein LengthFull Length of Mature ProteinPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDO43745
Background Information
  • Uniprot Id

    O43745

  • Target Species

    Human

  • Target Name

    CHP2

  • Target Full Name

    Calcineurin B homologous protein 2

  • Target Function

    Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.

  • Target Subcellular Location

    Nucleus. Cytoplasm. Cell membrane.

  • Target Protein Families

    Calcineurin regulatory subunit family, CHP subfamily

  • Target Tissue Specificity

    Expressed in malignantly transformed cells but not detected in normal tissues.

  • Target Synonyms

    CHP2; HCA520Calcineurin B homologous protein 2; Hepatocellular carcinoma-associated antigen 520

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