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Recombinant Human Calcium/calmodulin-dependent protein kinase type 1D (CAMK1D)

ACP15119

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP15119 Target NameCAMK1D
FormLyophilized powderExpression SystemCustom Production. Please inquire and provide the desire expression system.
Expression Range1-385Protein LengthFull length protein
Purity>85% (SDS-PAGE)Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ8IU85
Background Information
  • Uniprot Id

    Q8IU85

  • Target Species

    Human

  • Target Name

    CAMK1D

  • Target Full Name

    Calcium/calmodulin-dependent protein kinase type 1D

  • Target Function

    Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.

  • Target Subcellular Location

    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear localization increases upon activation by KCl treatment in hippocampal neurons.

  • Target Protein Families

    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily

  • Target Tissue Specificity

    Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes.

  • Target Synonyms

    A630059D12Rik; Calcium/calmodulin dependent protein kinase ID ; Calcium/calmodulin dependent protein kinase type 1D; Calcium/calmodulin-dependent protein kinase I-delta; Calcium/calmodulin-dependent protein kinase type 1D; CaM K1; CaM KI delta ; CaM kinase I delta; CaM kinase ID; CaM-KI delta; CAMK 1D; CAMK1D; CaMKI delta; CamKI like protein kinase; CamKI-like protein kinase; CaMKID ; CKLiK; E030025C11Rik; KCC1D_HUMAN; OTTHUMP00000019119; OTTHUMP00000019120; OTTHUMP00000045030; RP11 462F15.1

  • Target Background

    This gene is a member of the calcium/calmodulin-dependent protein kinase 1 family, a subfamily of the serine/threonine kinases. The encoded protein is a component of the calcium-regulated calmodulin-dependent protein kinase cascade. It has been associated with multiple processes including regulation of granulocyte function, activation of CREB-dependent gene transcription, aldosterone synthesis, differentiation and activation of neutrophil cells, and apoptosis of erythroleukemia cells. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.

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