Recombinant Human Calcyclin-binding protein (CACYBP)

Uniprot Id

Q9HB71

Target Species

Human

Target Name

CACYBP

Target Full Name

Calcyclin-binding protein

Target Function

May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).

Target Subcellular Location

Nucleus. Cytoplasm. Note=Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated.

Target Synonyms

CacyBP; Calcyclin binding protein; Calcyclin-binding protein; CYBP_HUMAN; GIG 5; GIG5; Growth inhibiting gene 5; Growth inhibiting gene 5 protein; hCacyBP; MGC87971; PNAS 107; PNAS107; RP1 102G20.6; S100A6 binding protein; S100A6-binding protein; S100A6BP; Siah-interacting protein; SIP

Target Background

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.