Recombinant Human Calpain-10 (CAPN10)

Cat.No	ACP12061	Target Name	CAPN10
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-672	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP12061

Target Name

CAPN10

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-672

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9HC96

Background Information

Uniprot Id

Q9HC96
Target Species

Human
Target Name

CAPN10
Target Full Name

Calpain-10
Target Function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake.
Target Involvement

Diabetes mellitus, non-insulin-dependent, 1 (NIDDM1)
Target Protein Families

Peptidase C2 family
Target Tissue Specificity

Detected in primary skeletal muscle cells (at protein level). Ubiquitous.
Target Synonyms

Calcium activated neutral protease ; Calcium activated neutral proteinase 10; Calcium-activated neutral proteinase 10; calpain like protease CAPN10; Calpain-10; Calpain10; CAN10_HUMAN; CANP 10; CANP10; CAPN 10; CAPN10; EC 3.4.22.; KIAA1845; NIDDM1
Target Background

Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.

Recombinant Human Calpain-10 (CAPN10)

Specifications

Immunogen Information

Inquire Recombinant Human Calpain-10 (CAPN10) Now

Related Products