Recombinant Human Calsyntenin-3 (CLSTN3), Truncated

Uniprot Id

Q9BQT9

Target Species

Human

Target Name

CLSTN3

Target Full Name

Calsyntenin-3

Target Function

May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell junction, synapse, postsynapse. Cell projection, dendrite.

Target Tissue Specificity

According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brai

Target Synonyms

CLSTN3; CS3; KIAA0726Calsyntenin-3; Alcadein-beta; Alc-beta

Target Background

Predicted to enable calcium ion binding activity. Predicted to be involved in positive regulation of synapse assembly and positive regulation of synaptic transmission. Predicted to act upstream of or within several processes, including chemical synaptic transmission; positive regulation of protein localization to synapse; and synapse assembly. Predicted to be located in postsynaptic density. Predicted to be part of protein-containing complex. Predicted to be active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Predicted to be integral component of postsynaptic density membrane.