Recombinant Human Carbonic anhydrase 12 (CA12), Truncated

Uniprot Id

O43570

Target Species

Human

Target Name

CA12

Target Full Name

Carbonic anhydrase 12

Target Function

Reversible hydration of carbon dioxide.

Target Involvement

Hyperchlorhidrosis, isolated (HCHLH)

Target Subcellular Location

Membrane; Single-pass type I membrane protein. Cell membrane.

Target Protein Families

Alpha-carbonic anhydrase family

Target Tissue Specificity

Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Expressed in sweat gl

Target Research Area

Cancer

Target Synonyms

CA 12; CA XII; CA-XII; CA12; CAH12_HUMAN; Carbonate dehydratase XII; Carbonic anhydrase 12; Carbonic anhydrase XII; Carbonic dehydratase; CAXII; FLJ20151; HsT18816; T18816; Tumor antigen HOM RCC 3.1.3; Tumor antigen HOM-RCC-3.1.3

Target Background

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene.