Recombinant Human Carbonic anhydrase 2 (CA2)

Uniprot Id

P00918

Target Species

Human

Target Name

CA2

Target Full Name

Carbonic anhydrase 2

Target Function

Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.

Target Involvement

Osteopetrosis, autosomal recessive 3 (OPTB3)

Target Subcellular Location

Cytoplasm. Cell membrane. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells.

Target Protein Families

Alpha-carbonic anhydrase family

Target Research Area

Signal Transduction

Target Synonyms

CA 2; CA II; CA-II; Ca2; CAC; CAH2_HUMAN; CAII; Car 2; Car2; Carbonate dehydratase II; Carbonic anhydrase 2; Carbonic anhydrase B; Carbonic anhydrase C; Carbonic anhydrase C; formerly; Carbonic anhydrase II; Carbonic dehydratase; epididymis luminal protein 76; Epididymis secretory protein Li 282; HEL-76; HEL-S-282

Target Background

The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene.