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The expression region of this recombinant Human CA9 covers amino acids 64-399. The theoretical molecular weight of the CA9 protein is 66.8 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 6xHis-GST tag into the CA9 encoding gene fragment was conducted, allowing for easier detection and purification of the CA9 protein in subsequent stages.Human carbonic anhydrase 9 (CA9) is a key enzyme involved in pH regulation and hypoxic adaptation. Primarily expressed in hypoxic tumor environments, CA9 facilitates the conversion of carbon dioxide to bicarbonate ions and protons. In cancer research, CA9 serves as a biomarker for hypoxia and tumor progression, offering diagnostic and prognostic insights. Targeting CA9 in anticancer strategies aims to disrupt pH homeostasis in tumor cells. Furthermore, CA9's involvement in acid-base balance makes it a subject of interest in nephrology and cardiovascular research.
The expression region of this recombinant Human CA9 covers amino acids 64-399. The theoretical molecular weight of the CA9 protein is 66.8 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 6xHis-GST tag into the CA9 encoding gene fragment was conducted, allowing for easier detection and purification of the CA9 protein in subsequent stages.Human carbonic anhydrase 9 (CA9) is a key enzyme involved in pH regulation and hypoxic adaptation. Primarily expressed in hypoxic tumor environments, CA9 facilitates the conversion of carbon dioxide to bicarbonate ions and protons. In cancer research, CA9 serves as a biomarker for hypoxia and tumor progression, offering diagnostic and prognostic insights. Targeting CA9 in anticancer strategies aims to disrupt pH homeostasis in tumor cells. Furthermore, CA9’s involvement in acid-base balance makes it a subject of interest in nephrology and cardiovascular research.
| Cat.No | ACP02656 | Target Name | CA9 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 64-399aa | Mol Weight | 66.8 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16790 |
|---|
Uniprot Id
Q16790
Target Species
Human
Target Name
CA9
Target Full Name
Carbonic anhydrase 9
Target Function
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
Target Subcellular Location
Nucleus. Nucleus, nucleolus. Cell membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus.
Target Protein Families
Alpha-carbonic anhydrase family
Target Tissue Specificity
Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.
Target Research Area
Metabolism
Target Synonyms
CA-IX; CA9; CAH9_HUMAN; CAIX; Carbonate dehydratase IX; Carbonic anhydrase 9; Carbonic anhydrase IX; Carbonic dehydratase; G250; Membrane antigen MN; MN; P54/58N; pMW1; RCC associated protein G250; RCC-associated antigen G250; Renal cell carcinoma-associated antigen G250
Target Background
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
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