Recombinant Human Carbonyl reductase family member 4 (CBR4)

Cat.No	ACP03244	Target Name	CBR4
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-237aa	Mol Weight	52.3kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03244

Target Name

CBR4

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-237aa

Mol Weight

52.3kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8N4T8

Background Information

Uniprot Id

Q8N4T8
Target Species

Human
Target Name

CBR4
Target Full Name

3-oxoacyl-[acyl-carrier-protein] reductase
Target Function

Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).
Target Subcellular Location

Mitochondrion matrix.
Target Protein Families

Short-chain dehydrogenases/reductases (SDR) family
Target Tissue Specificity

Detected in liver and kidney (at protein level). Displays the highest expression in neuronal and muscle tissues.
Target Research Area

Signal Transduction
Target Synonyms

3 oxoacyl [acyl carrier protein] reductase; 3-oxoacyl-[acyl-carrier-protein] reductase; Carbonic reductase 4; Carbonyl reductase 4; Carbonyl reductase family member 4; CBR 4; Cbr4; CBR4_HUMAN; FLJ14431; Quinone reductase CBR4; SDR45C1; Short chain dehydrogenase/reductase family 45C member 1
Target Background

Enables several functions, including 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity; NADPH binding activity; and NADPH dehydrogenase (quinone) activity. Involved in fatty acid biosynthetic process; glycoside metabolic process; and protein tetramerization. Located in mitochondrial matrix. Part of oxidoreductase complex.

Recombinant Human Carbonyl reductase family member 4 (CBR4)

Specifications

Immunogen Information

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