Recombinant Human Carboxylesterase 3 (CES3)

Uniprot Id

Q6UWW8

Target Species

Human

Target Name

CES3

Target Full Name

Carboxylesterase 3

Target Function

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.

Target Subcellular Location

Endoplasmic reticulum lumen.

Target Protein Families

Type-B carboxylesterase/lipase family

Target Tissue Specificity

Expressed in liver, colon and small intestine.

Target Research Area

Metabolism

Target Synonyms

Carboxylesterase 3; CES 3; Ces3; ES3; EST3_HUMAN; FLJ21736; Liver carboxylesterase 31 homolog

Target Background

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.