Recombinant Human Carboxypeptidase N catalytic chain (CPN1)

Uniprot Id

P15169

Target Species

Human

Target Name

CPN1

Target Full Name

Carboxypeptidase N catalytic chain

Target Function

Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.

Target Involvement

Carboxypeptidase N deficiency (CPND)

Target Subcellular Location

Secreted, extracellular space.

Target Protein Families

Peptidase M14 family

Target Tissue Specificity

Synthesized in the liver and secreted in plasma.

Target Research Area

Signal Transduction

Target Synonyms

ACBP; Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N catalytic chain; Carboxypeptidase N polypeptide 1 50 kD; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Carboxypeptidase N subunit 1; CBPN_HUMAN; CPN; CPN1; Kininase 1; Kininase-1; Kininase1; Lysine carboxypeptidase; Plasma carboxypeptidase B; SCPN; Serum carboxypeptidase N

Target Background

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.