Recombinant Human Cartilage acidic protein 1 (CRTAC1)

Uniprot Id

Q9NQ79

Target Species

Human

Target Name

CRTAC1

Target Full Name

Cartilage acidic protein 1

Target Subcellular Location

Secreted, extracellular space, extracellular matrix.

Target Tissue Specificity

Expressed in the interterritorial matrix of articular deep zone cartilage (at protein level). Isoform 1 and isoform 2 are expressed in brain. Isoform 1 is detected in lung and chondrocytes. Detected in cartilage, bone, cultured chondrocytes and lung, and

Target Synonyms

68 kDa chondrocyte expressed protein; 68 kDa chondrocyte-expressed protein; Acidic secreted protein in cartilage; ASPIC; ASPIC1; Cartilage acidic protein 1; Cartilage acidic protein 1 precursor; CEP 68 ; CEP-68; CEP68 ; Chondrocyte expressed protein 68 kDa CEP 68; CRAC1_HUMAN; CRTAC1; Protein CRTAC1-B; W307

Target Background

This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants.