Home Products Recombinant Human Cartilage intermediate layer protein 1 (CILP), Truncated

Recombinant Human Cartilage intermediate layer protein 1 (CILP), Truncated

ACP03456

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Specifications

Cat.No	ACP03456	Target Name	CILP
Form	Liquid or Lyophilized powder	Expression System	Baculovirus
Expression Range	725-1184aa	Mol Weight	95.7 kDa
Protein Length	Partial	Purity	Greater than 85% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O75339

Background Information

Uniprot Id

O75339
Target Species

Human
Target Name

CILP
Target Full Name

Cartilage intermediate layer protein 1
Target Function

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
Target Involvement

Intervertebral disc disease (IDD)
Target Subcellular Location

Secreted, extracellular space, extracellular matrix.
Target Tissue Specificity

Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in
Target Research Area

Immunology
Target Synonyms

Cartilage intermediate layer protein 1; Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2; cartilage intermediate layer protein; cartilage intermediate layer protein; nucleotide pyrophosphohydrolase; Cartilage intermediate-layer protein; CILP 1; CILP; CILP-1; CILP1_HUMAN; HGNC:1980; HsT18872

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Recombinant Human Cartilage intermediate layer protein 1 (CILP), Truncated

Specifications

Immunogen Information

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