Recombinant Human CCR4-NOT transcription complex subunit 6 (CNOT6)

Uniprot Id

Q9ULM6

Target Species

Human

Target Name

CNOT6

Target Full Name

CCR4-NOT transcription complex subunit 6

Target Function

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

CCR4/nocturin family

Target Synonyms

A230103N10Rik; AA407540; AW456442; carbon catabolite repression 4 protein; Carbon catabolite repressor protein 4 homolog; CCR4; CCR4 carbon catabolite repression 4 like; CCR4 carbon catabolite repression 4-like; CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex; subunit 6; Cnot6; CNOT6_HUMAN; Cytoplasmic deadenylase; EC 3.1.-.-; fa03c11; fc17f01; KIAA1194; MGC98472; OTTHUMP00000161544; wu:fa03c11; wu:fc17f01; zgc:65822