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Amino acids 22-321 constitute the expression domain of recombinant Human CD177. This CD177 protein is expected to have a theoretical molecular weight of 63.6 kDa. This protein is generated in a e.coli-based system. The CD177 gene fragment has been modified by fusing the N-terminal 6xHis-GST tag, providing convenience in detecting and purifying the recombinant CD177 protein during the following stages.The human CD177 antigen is a glycoprotein expressed on the surface of neutrophils, a type of white blood cell involved in the immune response. CD177 is a member of the Ly-6 superfamily and contains a glycosylphosphatidylinositol (GPI) anchor that tethers it to the cell membrane. It plays a role in neutrophil adhesion and migration, interacting with other molecules in the immune system. CD177 expression can vary among individuals, and alterations in its levels have been associated with certain diseases, including vasculitis. Understanding the functions of CD177 contributes to the comprehension of neutrophil biology and immune responses in health and disease.
Amino acids 22-321 constitute the expression domain of recombinant Human CD177. This CD177 protein is expected to have a theoretical molecular weight of 63.6 kDa. This protein is generated in a e.coli-based system. The CD177 gene fragment has been modified by fusing the N-terminal 6xHis-GST tag, providing convenience in detecting and purifying the recombinant CD177 protein during the following stages.The human CD177 antigen is a glycoprotein expressed on the surface of neutrophils, a type of white blood cell involved in the immune response. CD177 is a member of the Ly-6 superfamily and contains a glycosylphosphatidylinositol (GPI) anchor that tethers it to the cell membrane. It plays a role in neutrophil adhesion and migration, interacting with other molecules in the immune system. CD177 expression can vary among individuals, and alterations in its levels have been associated with certain diseases, including vasculitis. Understanding the functions of CD177 contributes to the comprehension of neutrophil biology and immune responses in health and disease.
| Cat.No | ACP01949 | Target Name | CD177 |
|---|---|---|---|
| Target Synonyms | Human neutrophil alloantigen 2a;HNA-2a;NB1 glycoprotein;NB1 GP;Polycythemia rubra vera protein 1;PRV-1;CD177 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 22-321aa |
| Mol Weight | 63.6 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N6Q3 |
|---|
Uniprot Id
Q8N6Q3
Target Species
Human
Target Name
CD177
Target Full Name
CD177 antigen
Target Function
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration. Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro. However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo. Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils. By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis.
Target Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Membrane raft; Lipid-anchor, GPI-like-anchor. Secreted. Cytoplasmic granule membrane. Cell projection, lamellipodium.
Target Tissue Specificity
Highly expressed in normal bone marrow and weakly expressed in fetal liver. During neutrophil differentiation, expression begins at the metamyelocyte stage and continues throughout the subsequent stages (at protein level). Expressed by a subset of mature
Target Research Area
Immunology
Target Synonyms
CD177; CD177 antigen; CD177 molecule; CD177_HUMAN; HNA-2a; HNA2A; Human neutrophil alloantigen 2a; NB1; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera 1; Polycythemia rubra vera protein 1; PRV-1; PRV1
Target Background
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified.
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