Recombinant Human CD180 antigen (CD180), Truncated

Uniprot Id

Q99467

Target Species

Human

Target Name

CD180

Target Full Name

CD180 antigen

Target Function

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Toll-like receptor family

Target Tissue Specificity

Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

Target Synonyms

CD180; CD180 antigen; CD180_HUMAN; F630107B15; LY64; Ly78; Lymphocyte antigen 64; lymphocyte antigen 64 radioprotective 105kDa; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; Radioprotective 105 kDa protein; RP105

Target Background

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.