Recombinant Human Cell adhesion molecule 2 (CADM2), Truncated

Uniprot Id

Q8N3J6

Target Species

Human

Target Name

CADM2

Target Full Name

Cell adhesion molecule 2

Target Function

Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, axon. Note=Found in the axoplasm of myelinated axons.

Target Protein Families

Nectin family

Target Synonyms

CADM2; CADM2_HUMAN; Cell adhesion molecule 2; IgSF4D; Immunoglobulin superfamily member 4D; NECL 2; Necl 3; NECL-3; NECL2; Necl3; Nectin like protein 3; Nectin-like protein 3; synCAM 2; synCAM2

Target Background

This gene encodes a member of the synaptic cell adhesion molecule 1 (SynCAM) family which belongs to the immunoglobulin (Ig) superfamily. The encoded protein has three Ig-like domains and a cytosolic protein 4.1 binding site near the C-terminus. Proteins belonging to the protein 4.1 family crosslink spectrin and interact with other cytoskeletal proteins. Multiple transcript variants encoding different isoforms have been found for this gene.