Recombinant Human Cell surface hyaluronidase (TMEM2), Truncated

Uniprot Id

Q9UHN6

Target Species

Human

Target Name

CEMIP2

Target Full Name

Cell surface hyaluronidase CEMIP2

Target Function

Unlike its mouse ortholog has no catalytic hyaluronic acid-degrading activity, but acts as a regulator of hyaluronan (HA) metabolism through regulation of expression of CEMIP and HAS2, two enzymes involved in HA depolymerization and HA synthesis, respectively.

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Target Protein Families

TMEM2 family

Target Tissue Specificity

Widely expressed.

Target Research Area

Cell Biology

Target Synonyms

KIAA1412; TMEM 2; tmem2; TMEM2_HUMAN; Transmembrane protein 2

Target Background

This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss.