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| Cat.No | ACP18924 | Target Name | CENPK |
|---|---|---|---|
| Target Synonyms | CENPK; ICEN37; FKSG14; Centromere protein K; CENP-K; Interphase centromere complex protein 37; Protein AF-5alpha; p33 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-269 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BS16 |
|---|
Uniprot Id
Q9BS16
Target Species
Human
Target Name
CENPK
Target Full Name
Centromere protein K
Target Function
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.
Target Involvement
Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.
Target Subcellular Location
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Target Protein Families
CENP-K/MCM22 family
Target Tissue Specificity
Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
CENPK; ICEN37; FKSG14; Centromere protein K; CENP-K; Interphase centromere complex protein 37; Protein AF-5alpha; p33
Target Background
CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).
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