Recombinant Human Cholesteryl ester transfer protein (CETP)

Uniprot Id

P11597

Target Species

Human

Target Name

CETP

Target Full Name

Cholesteryl ester transfer protein

Target Function

Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL. Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination.

Target Involvement

Hyperalphalipoproteinemia 1 (HALP1)

Target Subcellular Location

Secreted.

Target Protein Families

BPI/LBP/Plunc superfamily, BPI/LBP family

Target Tissue Specificity

Expressed by the liver and secreted in plasma.

Target Synonyms

BPIFF; CETP; CETP_HUMAN; Cholesteryl ester transfer protein; Cholesteryl ester transfer protein plasma; HDLCQ10; Lipid transfer protein I

Target Background

The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene.