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The generation of the recombinant Human SLC44A4 protein involves manipulating gene expression in e.coli cells. A specific DNA sequence coding for the Human SLC44A4 protein (56-229aa) is inserted to an expression vector, which is then introduced into e.coli cells. The cells that successfully receive the vector are selected and cultured to induce the expression of the desired protein. A N-terminal 10xHis tag and C-terminal Myc tag is attached to the protein. The recombinant Human SLC44A4 protein undergoes affinity purification, achieving a purity level exceeding 90%, as verified through SDS-PAGE analysis.
The generation of the recombinant Human SLC44A4 protein involves manipulating gene expression in e.coli cells. A specific DNA sequence coding for the Human SLC44A4 protein (56-229aa) is inserted to an expression vector, which is then introduced into e.coli cells. The cells that successfully receive the vector are selected and cultured to induce the expression of the desired protein. A N-terminal 10xHis tag and C-terminal Myc tag is attached to the protein. The recombinant Human SLC44A4 protein undergoes affinity purification, achieving a purity level exceeding 90%, as verified through SDS-PAGE analysis.
| Cat.No | ACP01083 | Target Name | SLC44A4 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 56-229aa | Mol Weight | 26.7 kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q53GD3 |
|---|
Uniprot Id
Q53GD3
Target Species
Human
Target Name
SLC44A4
Target Full Name
Choline transporter-like protein 4
Target Function
Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury. Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis.; Has also thiamine pyrophosphate transporter activity.
Target Involvement
Deafness, autosomal dominant, 72 (DFNA72)
Target Subcellular Location
Membrane; Multi-pass membrane protein. Apical cell membrane.
Target Protein Families
CTL (choline transporter-like) family
Target Tissue Specificity
Highly expressed in colon, also detected in prostate, trachea and lung. Isoform 3 is also expressed in colon but a lower levels.
Target Research Area
Others
Target Synonyms
C6orf29; Choline transporter-like protein 4; CTL4; CTL4_HUMAN; NG22; Slc44a4; Solute carrier family 44 member 4; UNQ441/PRO874
Target Background
The protein encoded by this gene may be a sodium-dependent transmembrane transport protein involved in the uptake of choline by cholinergic neurons. Defects in this gene can cause sialidosis, a lysosomal storage disease. Three transcript variants encoding different isoforms have been found for this gene.
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